癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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MBOAT4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96T53 |
| Other Accession | Q96T53 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49716 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Ghrelin O acyltransferase |
| Epitope Specificity | 101-200/435 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the membrane-bound acyltransferase family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MBOAT4 (membrane-bound O-acyltransferase domain-containing protein 4, Ghrelin O-acyltransferase) is a 435 amino acid, multi-pass membrane protein that belongs to the membrane-bound acyltransferase family. MBOAT4 functions as an enzyme that attaches an octanoate fatty acid to serine-3 of ghrelin. Ghrelin is a very small, appetite-stimulating hormone secreted by the food-deprived stomach. MBOAT4 can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid. MBOAT4 expression, consistent with its function, is mainly in the stomach and intestines. Due to its primary function, MBOAT4 is a candidate for obesity and appetite suppression studies. |
| Gene ID | 619373 |
|---|---|
| Other Names | FKSG89; GOAT; OACT4; Gm171; MBOA4_HUMAN; MBOAT4; Membrane-bound O-acyltransferase domain-containing protein 4 (O-acyltransferase domain-containing protein 4); 2.3.1.-; MBOA4_MOUSE; membrane bound ghrelin O-acyltransferase MBOAT4; membrane bound O-acyltransferase domain containing 4; O-acyltransferase (membrane bound) domain containing 4; ghrelin O-acyltransferase |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MBOAT4 (HGNC:32311) |
|---|---|
| Synonyms | GOAT, OACT4 |
| Function | Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:18443287, PubMed:24045953, PubMed:25562443, PubMed:28134508). In vitro also uses acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl- CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:18443287). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0C7A3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P0C7A3} |
| Tissue Location | Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels in most other tissues |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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