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GPR136 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q6U736 |
| Other Accession | Q6U736 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39727 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human G protein-coupled receptor 136 |
| Epitope Specificity | 11-110/354 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. |
| Post-translational modifications | It is uncertain whether Cys-315 or Cys-316 is palmitoylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GPCR GPR136, also known as Opsin 5, is a member of the guanine nucleotide binding protein (G protein) coupled receptor superfamily. This gene belongs to the seven exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven exon opsin genes, this gene may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants encoding different isoforms. ESTs for the GPR136 gene have been identified from human normal testis and B cell/lung/testis libraries.. |
| Gene ID | 221391 |
|---|---|
| Other Names | OPN5_HUMAN; OPN5; G-protein coupled receptor 136; G-protein coupled receptor PGR12; Neuropsin; Transmembrane protein 13; GPR136; PGR12; TMEM13; OPN5_MOUSE; Q7TQN6_RAT; opsin 5 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OPN5 (HGNC:19992) |
|---|---|
| Synonyms | GPR136, PGR12, TMEM13 |
| Function | G protein-coupled photoreceptor that selectively activates G(i) protein in response to light in the retina (By similarity). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (PubMed:22043319). Acts as a bistable protein with absorption peaks at 380 nm (UVA light) and 470 nm (blue light), allowing photoreversible regeneration of the cis-retinal chromophore after stimulation (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake. Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock. Acts as a circadian photoreceptor in the outer ear and vibrissal pads, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle. Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling. Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels. Mediates violet light-accelerated wound healing in corneas, being transiently expressed following physical injury (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q6VZZ7}; Multi-pass membrane protein |
| Tissue Location | Detected in brain and retina and cell lines derived from neural retina. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99298
