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CCBP2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O00590 |
| Other Accession | O00590 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43443 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CCBP2 |
| Epitope Specificity | 201-300/384 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the G-protein coupled receptor 1 family. |
| Post-translational modifications | Phosphorylated on serine residues in the C-terminal cytoplasmic tail. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Chemokine Receptor D6 is a member of the C-C (β chemokine) G protein-coupled receptor family. This family is characterized by a pair of adjacent cysteine residues. C-C chemokine receptor family members also include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7, CKR-8, CKR-9, CKR-10, CCXCKR, Bonzo, BOB (brother of Bonzo) and Duffy blood group antigen. Each of these receptors are G protein-coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to sites of inflammation. Chemokine Receptor D6 acts as a receptor for various C-C type chemokines, including SCYA2/MCP-1, SCY3/MIP-1-α, SCYA5/RANTES and SCYA7/MCP-3. It is expressed primarily in placental tissues and fetal liver, but is also detected in lymphatic endothelial cells, lymph nodes and mucosa of the small and large intestines. |
| Gene ID | 1238 |
|---|---|
| Other Names | CCBP2; CCR10; CCR9; CMKBR9; D6; hD6; ACKR2_HUMAN; ACKR2; C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein 2; Chemokine-binding protein D6; atypical chemokine receptor 2; chemokine binding protein 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ACKR2 |
|---|---|
| Synonyms | CCBP2, CCR10, CMKBR9, D6 |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis (PubMed:18201974, PubMed:20373092, PubMed:23479571). Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor (PubMed:18201974, PubMed:20373092, PubMed:23479571). Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3 (PubMed:18201974, PubMed:20373092, PubMed:23479571). Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)- dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway (PubMed:23633677). Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses (PubMed:23479571). Plays a major role in the immune silencing of macrophages during the resolution of inflammation (By similarity). Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs (PubMed:23479571). |
| Cellular Location | Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits (PubMed:18201974). Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (PubMed:18201974). |
| Tissue Location | Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99326
