癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KIAA1609 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6P9B6 |
| Other Accession | Q6P9B6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50994 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KIAA1609 |
| Epitope Specificity | 261-360/456 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 TLD domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KIAA1609 is a 456 amino acid protein that contains one TLD domain and is encoded by a gene that maps to human chromosome 16q24.1. Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. |
| Gene ID | 57707 |
|---|---|
| Other Names | EAK7; KIAA1609; TLDC1; mEAK-7; MEAK7_HUMAN; MEAK7; MTOR associated protein, eak-7 homolog; TBC/LysM-associated domain-containing protein 1; TLD domain-containing protein 1; MTOR associated protein MEAK7; TBC/LysM-associated domain containing 1; TLD domain containing 1; mammalian EAK-7 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MEAK7 (HGNC:29325) |
|---|---|
| Synonyms | KIAA1609, TLDC1 |
| Function | Activates an alternative mTOR signaling pathway through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). Binds to the vacuolar-type ATPase (V-ATPase) complex, triggering a conformational change and is likely to regulate its activity (PubMed:35672408, PubMed:35994636). No effect on V-ATPase activity was observed in vitro in one study although it was suggested that it may have inhibitory activity in vivo (PubMed:35672408). However, another study showed that it can promote V-ATPase activity (PubMed:38593795). Protects neuronal cells against oxidative stress (By similarity). |
| Cellular Location | Membrane. Cytoplasm. Lysosome |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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