癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OIF Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P20774 |
| Other Accession | P20774 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33922 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human OIF |
| Epitope Specificity | 101-200/298 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.Contains 7 LRR (leucine-rich) repeats. |
| Post-translational modifications | N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The small leucine-rich proteoglycan (SLRP) family of proteins contains various proteins such as Decorin, Biglycan, Fibromodulin, Keratocan, Lumican, Osteoadherin and Osteoglycin. These proteins all have similar functions as they all mediate extracellular matrix organization and act as binding partners of TGF beta. Osteoglycin, which also may be designated osteoinductive factor (OIF), is a secreted protein detected in bone tissues. Osteoglycin induces the formation of bone in conjunction with either TGF-beta-1 or TGF-beta-2. The precursor form of the OGN gene product, designated Mimecan, is subject to in situ proteolytic cleavage to yield the mature Osteoglycin. |
| Gene ID | 4969 |
|---|---|
| Other Names | OG; OIF; SLRR3A; MIME_HUMAN; OGN; Osteoglycin; Osteoinductive factor (OIF); osteoglycin (osteoinductive factor); mimecan proteoglycan |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OGN |
|---|---|
| Synonyms | OIF, SLRR3A |
| Function | Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8MJF1} |
| Tissue Location | Bone. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99369
