癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TSPO/PBR Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | B1AH88 |
| Other Accession | B1AH88 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 10537 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PBR |
| Epitope Specificity | 31-130/169 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the TspO/BZRP family. |
| SUBUNIT | Interacts with TSPOAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR. |
| Other Names | BPBS; BZRP; DBI; IBP; MBR; PBR; PBS; PKBS; PTBR; TSPO1; mDRC; pk18; TSPOB_HUMAN; TSPO; PBRS; TSPO_HUMAN; Mitochondrial benzodiazepine receptor; Peripheral-type benzodiazepine receptor (PBR); TSPO_MOUSE; translocator protein; benzodiazapine receptor (peripheral); translocator protein (18kDa); peripheral-type benzodiazepine receptor/recognition site |
|---|---|
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TSPO |
|---|---|
| Synonyms | PBRS |
| Tissue Location | Ubiquitous. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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