癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KRT28 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q7Z3Y7 |
| Other Accession | Q7Z3Y7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50567 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KRT28 |
| Epitope Specificity | 161-260/464 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the intermediate filament family. |
| SUBUNIT | Heterotetramer of two type I and two type II keratins. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009] |
| Gene ID | 162605 |
|---|---|
| Other Names | KRT10; K25IRS4; KRT25D; 4733401L19Rik; CK-28; K25D; K28; K1C28_BOVIN; KRT28; Cytokeratin-28 (CK-28); Keratin-28 (K28); Type I inner root sheath-specific keratin-K25irs4; K1C28_HUMAN; Keratin-25D (K25D); K1C28_MOUSE; keratin 28; keratin 25D; keratin 28, type I |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT28 (HGNC:30842) |
|---|---|
| Function | Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:A6BLY7}. |
| Tissue Location | Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers Also present in the medulla of beard hair (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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