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KCP2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8N6L1 |
| Other Accession | Q8N6L1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 14679 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KCP2 |
| Epitope Specificity | 81-136/136 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the KRTCAP2 family. |
| SUBUNIT | Component of the oligosaccharyltransferase (OST) complex.OST seems to exist in different forms which contain at least RPN1,RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with STT3A. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. |
| Gene ID | 200185 |
|---|---|
| Other Names | KCP2; 0610010I12Rik; KTAP2_HUMAN; KRTCAP2; Oligosaccharyl transferase subunit KCP2; Keratinocyte-associated protein 2 (KCP-2); KTAP2_MOUSE; keratinocyte associated protein 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRTCAP2 |
|---|---|
| Synonyms | KCP2 {ECO:0000303|PubMed:28860277} |
| Function | Subunit of STT3A-containing oligosaccharyl transferase (OST- A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853, PubMed:28860277). N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:22467853, PubMed:28860277). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex (PubMed:28860277). May be involved in N-glycosylation of APP (amyloid- beta precursor protein) (PubMed:21768116). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116). |
| Cellular Location | Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes and dermal fibroblasts. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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