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CDCA3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q99618 |
| Other Accession | Q99618 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28998 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CDCA3 |
| Epitope Specificity | 201-268/268 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBUNIT | Protein modification; protein ubiquitination. [SUBUNIT] Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). |
| Post-translational modifications | Ubiquitinated and degraded by the APC/C-Cdh1 complex (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CDCA3 (Cell division cycle associated 3) is an F-box-like protein which is required for entry into mitosis. It is associated with SKP1 as part of a SCF (SKP1-cullin-F-box) protein ligase complex, and is required for the ubiquitination and degradation of the CDK1 inhibitory tyrosine kinase WEE1 at G2/M phase. |
| Gene ID | 83461 |
|---|---|
| Other Names | CDCA3_HUMAN; CDCA3; Gene-rich cluster protein C8; Trigger of mitotic entry protein 1 (TOME-1); C8; GRCC8; TOME1; CDCA3_XENLA; CDCA3_MOUSE; CDCA3_RAT; TOME-1; 2410005A12Rik; cell division cycle associated 3; trigger of mitotic entry 1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CDCA3 |
|---|---|
| Synonyms | C8, GRCC8, TOME1 |
| Function | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). |
| Cellular Location | Cytoplasm, cytosol. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99407
