癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BCMP11 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8TD06 |
| Other Accession | Q8TD06 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 19171 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human BCMP11/AGR3 |
| Epitope Specificity | 65-160/166 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the AGR family. |
| SUBUNIT | nteracts with LYPD3 and DAG1 (alphaDAG1). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | AGR3 is a secreted extracellular protein. It is a member of the anterior gradient homolog family. AGR3 shares a high degree of sequence homology with AGR2, the human ortholog of XAG-2 (the secreted Xenopus laevis Anterior Gradient protein). AGR3 interacts with lypd3 and ?dystroglycan. AGR3 is highly prevalent in breast cancers and may serve as a potential therapeutic marker. |
| Gene ID | 155465 |
|---|---|
| Other Names | AG-3; AG3; BCMP11; HAG3; PDIA18; hAG-3; AGR3_HUMAN; AGR3; Anterior gradient 3 homolog; Breast cancer membrane protein 11; Protein disulfide isomerase family A, member 18; anterior gradient 3, protein disulphide isomerase family member; anterior gradient 3 homolog (Xenopus laevis) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | AGR3 |
|---|---|
| Synonyms | BCMP11, PDIA18 |
| Function | Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. |
| Cellular Location | Endoplasmic reticulum. Note=Found in the cytoplasm, which could include the endoplasmic reticulum |
| Tissue Location | Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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