癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PCSK2/Proprotein Convertase 2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P16519 |
| Other Accession | P16519 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70565 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Proprotein Convertase 2 |
| Epitope Specificity | 201-300/638 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the peptidase S8 family. Furin subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]. |
| Gene ID | 5126 |
|---|---|
| Other Names | NEC 2; NEC-2; NEC2; PC2; SPC2; 6330411F23Rik; Phpp-2; NEC2_HUMAN; PCSK2; KEX2-like endoprotease 2; Prohormone convertase 2; Proprotein convertase 2 (PC2); 3.4.21.94; NEC2_MOUSE; proprotein convertase subtilisin/kexin type 2; neuroendocrine convertase 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PCSK2 |
|---|---|
| Synonyms | NEC2 |
| Function | Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (PubMed:28719828, PubMed:7626024, PubMed:8879041, PubMed:9287128). Responsible for the release of glucagon from proglucagon in pancreatic A cells (PubMed:9287128). Mediates the release of insulin from proinsulin (PubMed:7626024). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Localized in the secretion granules |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99450
