癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KLHL6 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8WZ60 |
| Other Accession | Q8WZ60 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70359 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KLHL6 |
| Epitope Specificity | 531-621/621 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 89857 |
|---|---|
| Other Names | KLHL6_HUMAN; KLHL6; KLHL6_MOUSE; kelch like family member 6; kelch-like 6 (Drosophila); kelch-like protein KLHL6 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KLHL6 |
|---|---|
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a multifunctional regulator of B- cell receptor (BCR) signaling, germinal center formation, and T-cell function. Functions by mediating polyubiquitination of target proteins, leading to their proteasomal degradation. In B-cells, plays an essential role in BCR signaling and germinal center B-cell maturation. Targets the BCR signaling subunits CD79A and CD79B for ubiquitin- mediated degradation, thereby controlling surface BCR homeostasis (PubMed:38630892). Mediates polyubiquitination and degradation of the mRNA decay factor roquin-2/RC3H2, which in turn allows accumulation of TNFAIP3, a negative regulator of NF-kappa-B signaling, thereby providing feedback inhibition of BCR-induced NF-kappa-B activation (PubMed:29695787). In T-cells, acts as a dual negative regulator of T- cell exhaustion and mitochondrial dysfunction. Promotes 'Lys-48'-linked polyubiquitination and proteasomal degradation of the transcription factor TOX, thereby attenuating the transition of progenitor exhausted T-cells towards terminal exhaustion (PubMed:41535474). Also targets the mitochondrial phosphatase PGAM5 for degradation, thereby preventing excessive PGAM5-mediated dephosphorylation and activation of DRP1, which would otherwise drive pathological mitochondrial fission (PubMed:41535474). Through these mechanisms, maintains mitochondrial fitness in T-cells during chronic antigen stimulation. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Found in germinal center B-cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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