癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DATF1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9BTC0 |
| Other Accession | Q9BTC0 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 243873 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DATF1 |
| Epitope Specificity | 1-100/2240 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the indoleamine 2,3-dioxygenase family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Apoptosis plays an important role in many cellular processes. In mice, the death inducer obliterator 1 (Dio1) gene, a putative transcription factor, is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. Dio1 expression is upregulated when an apoptosis is detected. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. Human DATF1 (death associated transcription factor 1) is similar to the mouse gene and therefore is thought to be involved in apoptosis. |
| Gene ID | 11083 |
|---|---|
| Other Names | BYE1; C20orf158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8; 6720461J16Rik; C130092D22Rik; D130048F08Rik; dido; DIDO1_HUMAN; DIDO1; hDido1; Death-associated transcription factor 1 (DATF-1); KIAA0333; DIDO1_MOUSE; death inducer-obliterator 1; chromosome 20 open reading frame 158; death associated transcription factor 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DIDO1 |
|---|---|
| Synonyms | C20orf158, DATF1, KIAA0333 |
| Function | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00651}. Cytoplasm, cytoskeleton, spindle. Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. |
| Tissue Location | Ubiquitous. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP99464
