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SERPINC1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P01008 |
| Other Accession | P01008 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Pig, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52602 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Antithrombin III |
| Epitope Specificity | 141-211/464 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the serpin family. |
| SUBUNIT | Forms protease inhibiting heterodimer with TMPRSS7. |
| Post-translational modifications | Phosphorylation sites are present in the extracellular medium. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]. |
| Gene ID | 462 |
|---|---|
| Other Names | AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; THPH7; At-3; ANT3_HUMAN; SERPINC1; Serpin C1; ANT3_MOUSE; serpin family C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; antithrombin III; signal peptide antithrombin part 1; coding sequence signal peptide antithrombin part 1; antithrombin (aa 375-432) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SERPINC1 |
|---|---|
| Synonyms | AT3 |
| Function | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15140129, PubMed:15853774). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibitory activity is greatly enhanced in the presence of heparin. |
| Cellular Location | Secreted, extracellular space. |
| Tissue Location | Found in plasma. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP99465
