癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DLK1 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P80370 |
| Other Accession | P80370 |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 41300 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DLK1 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.22 µm filtered solution in 20mM hepes7.4, 150mm NaCl, 50% glycerin,0.03% proclin. |
| SIMILARITY | Contains 6 EGF-like domains. |
| SUBUNIT | Monomer. |
| Post-translational modifications | N- and O-glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]. |
| Gene ID | 8788 |
|---|---|
| Other Names | DLK; DLK-1; Delta1; FA1; PREF1; Pref-1; ZOG; pG2; DlkI; Ly107; Peg9; SCP1; DLK1_HUMAN; DLK1; DLK1_MOUSE; Adipocyte differentiation inhibitor protein; Preadipocyte factor 1 (Pref-1); Scp-1; delta like non-canonical Notch ligand 1; delta-like homolog (Drosophila); delta-like 1 homolog (Drosophila) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DLK1 |
|---|---|
| Synonyms | DLK |
| Function | May have a role in neuroendocrine differentiation. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O70534} |
| Tissue Location | Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99561
