癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
VDAC3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9Y277 |
| Other Accession | Q9Y277 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30659 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human VDAC3 |
| Epitope Specificity | 101-200/283 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the eukaryotic mitochondrial porin family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| Gene ID | 7419 |
|---|---|
| Other Names | VDAC1P5; VDAC5P; HD-VDAC3; VDAC-3; VDAC3_BOVIN; VDAC3; Outer mitochondrial membrane protein porin 3; VDAC3_HUMAN; hVDAC3; VDAC3_MOUSE; mVDAC3; VDAC3_RABIT; VDAC3_RAT; rVDAC3; voltage dependent anion channel 3 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | VDAC3 (HGNC:12674) |
|---|---|
| Function | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (PubMed:31935282). Involved in male fertility and sperm mitochondrial sheath formation (By similarity). |
| Cellular Location | Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21796}. Membrane Note=May localize to non-mitochondrial membranes |
| Tissue Location | Expressed in erythrocytes (at protein level) (PubMed:27641616). Widely expressed. Highest in testis (PubMed:9781040). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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