SLC16A10 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, IHC-F, IF
Primary Accession	Q8TF71
Other Accession	Q8TF71
Reactivity	Human, Mouse
Predicted	Rat
Host	Rabbit
Clonality	Polyclonal
Calculated MW	55493 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human SLC16A10
Epitope Specificity	121-220/515
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Post-translational modifications	Not N-glycosylated.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Additional Information
Gene ID	117247
Other Names	MCT10; PRO0813; TAT1; 2610103N14Rik; 9830169E08; MOT10_HUMAN; SLC16A10; MCT 10; Aromatic amino acid transporter 1; Solute carrier family 16 member 10; T-type amino acid transporter 1; MOT10_MOUSE; MOT10_RAT; solute carrier family 16 (monocarboxylic acid transporters), member 10; solute carrier family 16 (aromatic amino acid transporter), member 10
Dilution	WB=1:500-2000,IHC-P=1:50-300,IHC-F=1:50-300,IF=1:50-300
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	SLC16A10
Synonyms	MCT10, TAT1 {ECO:0000303\|PubMed:11827462
Function	Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4- dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity).
Cellular Location	Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250\|UniProtKB:Q91Y77}; Multi-pass membrane protein
Tissue Location	Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart