癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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CDCA8 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q53HL2 |
| Other Accession | Q53HL2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31323 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Borealin/CDCA8 |
| Epitope Specificity | 20-120/280 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the borealin family. |
| SUBUNIT | May form homooligomers and homodimers. |
| Post-translational modifications | Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230. Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. |
| Gene ID | 55143 |
|---|---|
| Other Names | BOR; BOREALIN; DasraB; MESRGP; 4831429J16Rik; D4Ertd421e; BOREA_HUMAN; CDCA8; Cell division cycle-associated protein 8; Dasra-B (hDasra-B); Pluripotent embryonic stem cell-related gene 3 protein; PESCRG3; BOREA_MOUSE; MESrg; BOREA_RAT; cell division cycle associated 8 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CDCA8 |
|---|---|
| Synonyms | PESCRG3 |
| Function | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. |
| Cellular Location | Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis Colocalizes with SENP3 in the nucleolus in interphase cells |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99617
