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CEP57 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q86XR8 |
| Other Accession | Q86XR8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57089 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CEP57 |
| Epitope Specificity | 51-150/500 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the translokin family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CEP57 (centrosomal protein 57kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88% sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events. |
| Gene ID | 9702 |
|---|---|
| Other Names | MVA2; PIG8; TSP57; 3110002L15Rik; 4921510P06Rik; 4931428M20Rik; mKIAA0092; RGD1309884; CEP57_BOVIN; CEP57; Testis-specific protein 57; Translokin; CEP57_HUMAN; FGF2-interacting protein; KIAA0092; CEP57_MOUSE; CEP57_RAT; centrosomal protein 57; centrosomal protein 57kDa |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CEP57 |
|---|---|
| Synonyms | KIAA0092, TSP57 |
| Function | Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. |
| Cellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| Tissue Location | Ubiquitous.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99620
