癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DENTT Rabbit pAb
- 产品详情
- 实验流程
| Primary Accession | Q9H2G4 |
|---|---|
| Other Accession | Q9H2G4 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 79435 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DENTT |
| Epitope Specificity | 251-350/693 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the nucleosome assembly protein (NAP) family. |
| SUBUNIT | Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2. |
| Post-translational modifications | Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CASK interacting nucleosome assembly protein (CINAP) modulates gene expression and its abundance in cultured neurons is regulated by synaptic activity. CINAP is widely expressed in different regions of adult mouse brain, including the cerebral cortex, hippocampus, striatum, hypothalamus, cerebellum, and two adult brain regions known to generate progenitor neurons. During early development, CINAP is also expressed in regions where neuronal progenitor cells are actively dividing, the ventricular and subventricular zones, suggesting that in addition to regulating gene expression in mature neurons CINAP may also play a role in dividing cells. |
| Gene ID | 64061 |
|---|---|
| Other Names | CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79; SE204; TSPX; DXBwg1396e; DXHXS1008E; E130307F10Rik; RGD1563283; TSYL2_HUMAN; TSPYL2; TSPY-like protein 2; Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4 (CTCL-associated antigen se20-4); Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa (NP79); TSYL2_MOUSE; CASK-interacting nucleosome assembly protein; TSPY like 2 |
| Dilution | ICC/IF=1:50-200 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TSPYL2 |
|---|---|
| Synonyms | CDA1, DENTT, TSPX |
| Function | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. |
| Cellular Location | Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons |
| Tissue Location | Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
¥ 1,250.00
Cat# AP99657
