癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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KAL1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P23352 |
| Other Accession | P23352 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 76112 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human AF-6/l Afadin |
| Epitope Specificity | 131-230/680 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 4 fibronectin type-III domains. Contains 1 WAP domain. |
| SUBUNIT | Interacts with FGFR1; this interaction does not interfere with FGF2-binding to FGFR1. Binds heparin. Heparin may promote or interfere with KAL1-FGFR1-FGF2 complex formation depending on the sequential order of its binding to the various constituents. For instance, heparin-KAL1 interaction favors subsequent binding to pre-existing binary FGFR1-FGF2 complex, while heparin-FGF2 complex does not interact with KAL1-FGFR1. |
| Post-translational modifications | N-glycosylated. |
| DISEASE | Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | May be an adhesion-like molecule with anti-protease activity. |
| Gene ID | 3730 |
|---|---|
| Other Names | ADMLX; HH1; HHA; KAL; KAL1; KALIG-1; KMS; WFDC19; KALM_HUMAN; ANOS1; Adhesion molecule-like X-linked; Kallmann syndrome protein; KALIG1; anosmin 1; Kallmann syndrome 1 sequence; anosmin-1; WAP four-disulfide core domain 19; Adhesion molecule-like, X-linked; Kallmann syndrome interval gene 1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ANOS1 (HGNC:6211) |
|---|---|
| Synonyms | ADMLX, KAL, KAL1, KALIG1 |
| Function | Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. |
| Cellular Location | Cell membrane; Peripheral membrane protein. Secreted. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space |
| Tissue Location | Expressed in the cerebellum (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99674
