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LARG Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9NZN5 |
| Other Accession | Q9NZN5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 173232 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LARG |
| Epitope Specificity | 515-615/1544 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 DH (DBL-homology) domain.Contains 1 PDZ (DHR) domain.Contains 1 PH domain.Contains 1 RGSL (RGS-like) domain. |
| SUBUNIT | Interacts with GNA12 and GNA13, probably through the RGS-like domain, with RHOA, PLXNB1 and PLXNB2, and through its PDZ domain with IGF1R beta subunit. |
| Post-translational modifications | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| DISEASE | Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia (from EntrezGene). LARG has also been implicated in linking heterotrimeric G proteins to microtubule organisation in regulation of cell polarity. |
| Gene ID | 23365 |
|---|---|
| Other Names | ARHGC_HUMAN; ARHGEF12; Leukemia-associated RhoGEF; KIAA0382; LARG; ARHGC_MOUSE; Rho guanine nucleotide exchange factor 12; Rho guanine nucleotide exchange factor (GEF) 12 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ARHGEF12 (HGNC:14193) |
|---|---|
| Function | Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 (PubMed:11094164). May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) (PubMed:11094164). Promotes endothelial cell and actin stress fiber reorientation in response to mechanotransduction (By similarity). |
| Cellular Location | Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation. |
| Tissue Location | Ubiquitously expressed. Isoform 2 is found in jejunum and testis |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99693
