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NAT8L Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8N9F0 |
| Other Accession | Q8N9F0 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32837 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NAT8L |
| Epitope Specificity | 201-302/302 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the camello family. Contains 1 N-acetyltransferase domain. |
| DISEASE | Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED) [MIM:614063]. A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). |
| Gene ID | 339983 |
|---|---|
| Other Names | CML3; NACED; NAT8-LIKE; 1110038O08Rik; Shati; NAT8L_HUMAN; NAT8L; NAA synthetase; Camello-like protein 3; N-acetyltransferase 8-like protein; 2.3.1.17; NAT8L_MOUSE; Protein Shati; N-acetyltransferase 8 like; N-acetyltransferase 8-like (GCN5-related, putative) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NAT8L (HGNC:26742) |
|---|---|
| Synonyms | CML3 |
| Function | Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA (PubMed:19524112, PubMed:19807691, PubMed:20385109). Promotes dopamine uptake by regulating TNF expression (By similarity). Attenuates methamphetamine-induced inhibition of dopamine uptake (PubMed:20385109). |
| Cellular Location | Cytoplasm. Microsome membrane {ECO:0000250|UniProtKB:D3ZVU9}; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q3UGX3}; Single-pass membrane protein. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. |
| Tissue Location | Expressed in brain.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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