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LDB2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O43679 |
| Other Accession | O43679 |
| Reactivity | Human |
| Predicted | Rat, Cat, Mouse, Rabbit, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42793 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LDB2 |
| Epitope Specificity | 1-100/373 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the LDB family. |
| Post-translational modifications | Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010] |
| Gene ID | 9079 |
|---|---|
| Other Names | CLIM1; LDB-2; LDB1; CLP-36; Ldb3; LDB2_CHICK; LDB2; Carboxyl-terminal LIM domain-binding protein 1 (CLIM-1); LIM domain-binding factor CLIM1 (cLdb2); LDB2_HUMAN; LIM domain-binding factor CLIM1; LDB2_MOUSE; B5DF10_RAT; LIM domain binding 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LDB2 |
|---|---|
| Synonyms | CLIM1 |
| Function | Transcription cofactor. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. |
| Cellular Location | Nucleus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99711
