癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LIAS Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O43766 |
| Other Accession | O43766 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41911 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LIAS |
| Epitope Specificity | 28-130/372 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the radical SAM superfamily. Lipoyl synthase family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] |
| Gene ID | 11019 |
|---|---|
| Other Names | HGCLAS; HUSSY-01; LAS; LIP1; LS; PDHLD; 2900022L22Rik; 4933425M12Rik; 7a5ex; lip-syn; zgc:66080; LIAS_BOVIN; LIAS; Lipoate synthase (LS | Lip-syn); Lipoic acid synthase; 2.8.1.8; LIAS_HUMAN; LIAS_MOUSE; Lipoate synthase (LS | Lip-syn | mLIP1); LIAS_RAT; lipoic acid synthetase; Lipoyl synthase, mitochondrial |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LIAS {ECO:0000255|HAMAP-Rule:MF_03123} |
|---|---|
| Synonyms | LAS |
| Function | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. |
| Cellular Location | Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03123}. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99718
