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SHANK2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UPX8 |
| Other Accession | Q9UPX8 |
| Reactivity | Mouse |
| Predicted | Rat, Human, Rabbit, Dog, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 201261 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SHANK2 |
| Epitope Specificity | 161-260/1470 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the SHANK family.Contains 1 PDZ (DHR) domain.Contains 1 SAM (sterile alpha motif) domain.Contains 1 SH3 domain. |
| SUBUNIT | Interacts with CTTN/cortactin SH3 domain, LGAP1/GKAP and alpha-latrotoxin receptor 1. Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with GRID2, SLC9A3, CFTR and PLCB3. Interacts with DBNL (By similarity). Interacts with DNM2. Interacts with BAIAP2. |
| DISEASE | All isoforms except isoform 7 are expressed predominantly in brain, with highest levels in olfactory bulb, cerebral cortex, cerebellum, central gray matter and hippocampus. Moderate levels of expression are seen in the caudate putamen, thalamic nuclei and brain stem. In cerebellum primarily expressed in Purkinje cells. Isoform 7 is not expressed in brain but expressed in liver, cholangiocytes and thymus. Isoform 7 is present in pancreas, colonic mucosa and thymocytes (at protein level). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SH3 and multiple ankyrin repeat domains 1-3 (Shank1-3) of the Shank/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). The PSD is an electron-dense structure underneath the postsynaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the presynaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). Shank recruits betaPIX and PAK to spines to regulate postsynaptic structure and interacts with NMDA receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. |
| Gene ID | 22941 |
|---|---|
| Other Names | AUTS17; CORTBP1; CTTNBP1; ProSAP1; SHANK; SPANK-3; mKIAA1022; Shank2E; SHAN2_HUMAN; SHANK2; Cortactin-binding protein 1 (CortBP1); Proline-rich synapse-associated protein 1; KIAA1022; SHAN2_MOUSE; SHAN2_RAT; GKAP/SAPAP-interacting protein; Proline-rich synapse-associated protein 1 (ProSAP1); SH3 and multiple ankyrin repeat domains 2; cortactin binding protein 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SHANK2 |
|---|---|
| Synonyms | CORTBP1, KIAA1022, PROSAP1 |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Cellular Location | Apical cell membrane. Cytoplasm. Synapse. Postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). |
| Tissue Location | Isoform 3 is present in epithelial colonic cells (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99722
