APOBEC1 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, IHC-F, IF, E
Primary Accession	P41238
Other Accession	P41238
Predicted	Human, Horse
Host	Rabbit
Clonality	Polyclonal
Calculated MW	28192 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human APOBEC1
Epitope Specificity	1-100/236
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SIMILARITY	Belongs to the cytidine and deoxycytidylate deaminase family.
SUBUNIT	Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	Post-transcriptional editing of apolipoprotein B (apoB) mRNA is regulated by This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. [provided by RefSeq, Jul 2008].

Additional Information
Gene ID	339
Other Names	APO1; APOBEC-1; BEDP; CDAR1; HEPR; ABEC1_HUMAN; APOBEC1; Apolipoprotein B mRNA-editing enzyme catalytic subunit 1 (APO1 \| APOBEC-1 \| Apolipoprotein B mRNA-editing enzyme 1); mRNA(cytosine(6666)) deaminase 1; 3.5.4.-; ABEC1_MOUSE; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1 \| Apolipoprotein B mRNA-editing enzyme 1); ABEC1_PONPY; apolipoprotein B mRNA editing enzyme catalytic subunit 1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Dilution	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	APOBEC1 (HGNC:604)
Function	Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity).
Cellular Location	Cytoplasm. Nucleus
Tissue Location	Expressed exclusively in the small intestine.