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CaMKK1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8N5S9 |
| Other Accession | Q8N5S9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 55735 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CaMKK1 |
| Epitope Specificity | 101-200/505 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. |
| SUBUNIT | Interacts with CAMK4 and calmodulin (By similarity). |
| Post-translational modifications | Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. |
| Gene ID | 84254 |
|---|---|
| Other Names | CAMKKA; CaMKKalpha; Camkk; caM-KK 1; caM-KK alpha; caMKK 1; caMKK alpha; KKCC1_HUMAN; CAMKK1; CaM-kinase kinase 1; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha (CaM-KK alpha | CaM-kinase kinase alpha | CaMKK alpha); 2.7.11.17; KKCC1_MOUSE; calcium/calmodulin dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; calcium/calmodulin-dependent protein kinase kinase alpha |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CAMKK1 |
|---|---|
| Synonyms | CAMKKA |
| Function | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2- antagonist of cell death. |
| Cellular Location | Cytoplasm. Nucleus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99744
