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OXCT1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P55809 |
| Other Accession | P55809 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56158 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human OXCT1 |
| Epitope Specificity | 211-310/520 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the 3-oxoacid CoA-transferase family. |
| DISEASE | Defects in OXCT1 are a cause of SCOT deficiency (SCOTD) [MIM:245050]. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. |
| Gene ID | 5019 |
|---|---|
| Other Names | OXCT; SCOT; 2610008O03Rik; Oxct2a; Scot-s; SCOT1_HUMAN; OXCT1; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase (SCOT-s); Succinyl-CoA:3-oxoacid CoA transferase; 2.8.3.5; SCOT1_MOUSE; SCOT1_RAT; 3-oxoacid CoA transferase; 3-oxoacid CoA transferase 1; Succinyl-CoA:3-ketoacid-CoA transferase |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OXCT1 |
|---|---|
| Synonyms | OXCT, SCOT |
| Function | Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl- CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (PubMed:10964512). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl- CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). |
| Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:B2GV06}. |
| Tissue Location | Abundant in heart, followed in order by brain, kidney, skeletal muscle, and lung, whereas in liver it is undetectable Expressed (at protein level) in all tissues (except in liver), most abundant in myocardium, then brain, kidney, adrenal glands, skeletal muscle and lung; also detectable in leukocytes and fibroblasts |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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