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phospho-PPIG (Ser376) Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q13427 |
| Other Accession | Q13427 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 88617 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated Synthesised phosphopeptide derived from human PPIG around the phosphorylation site of Ser376 |
| Epitope Specificity | VS(p-S)GE |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 PPIase cyclophilin-type domain. |
| SUBUNIT | Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II. |
| Post-translational modifications | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PPIG belongs to the the peptidyl-prolyl cis/trans isomerase protein family (PPIases). PPIases accelerate the folding of proteins. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is implicated in the folding, transport, and assembly of proteins. It is distributed in nuclear speckles, a nuclear compartment rich in splicing factors, and colocalizes with the splicing factors SC35 and pinin, suggesting a role in the regulation of pre-mRNA splicing. |
| Gene ID | 9360 |
|---|---|
| Other Names | CARS-Cyp; CYP; SCAF10; SRCyp; B230312B02Rik; PPIG_HUMAN; PPIG; PPIase G; Peptidyl-prolyl isomerase G; CASP10; Clk-associating RS-cyclophilin (CARS-Cyp | CARS-cyclophilin | SR-cyclophilin | SR-cyp | SRcyp); Cyclophilin G; Rotamase G; 5.2.1.8; PPIG_MOUSE; PPIG_RAT; Matrin cyclophilin (Matrin-cyp); peptidylprolyl isomerase G; SR-related CTD-associated factor 10; PPIG (phospho-S376); p-PPIG; phospho-PPIG; PPIG (phospho-Ser376) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PPIG |
|---|---|
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. |
| Cellular Location | Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles |
| Tissue Location | Ubiquitous.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99774
