癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PDE4C Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q08493 |
| Other Accession | Q08493 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 79902 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PDE4C |
| Epitope Specificity | 1-100/712 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| Gene ID | 5143 |
|---|---|
| Other Names | DPDE1; PDE21; E130301F19Rik; dunce; PDE4C_HUMAN; PDE4C; cAMP-specific phosphodiesterase 4C; 3.1.4.53; PDE4C_MOUSE; PDE4C_RAT; phosphodiesterase 4C; phosphodiesterase 4C, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E1); phosphodiesterase 4C, cAMP-specific; phosphodiesterase E1 dunce homolog (Drosophila) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PDE4C (HGNC:8782) |
|---|---|
| Synonyms | DPDE1 |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
| Cellular Location | Cell projection, cilium {ECO:0000250|UniProtKB:Q3UEI1} |
| Tissue Location | Expressed in various tissues but not in cells of the immune system. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99806
