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HCN2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UL51 |
| Other Accession | Q9UL51 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 96950 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HCN2 |
| Epitope Specificity | 288-350/889 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the potassium channel HCN family. Contains 1 cyclic nucleotide-binding domain. |
| SUBUNIT | The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1–4), each with a core transmembrane segment domain and a carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif (1). HCN channels are expressed in the brain, heart, thalamus and testis (1). The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart (1). The genes encoding human HCN1 and HCN2 map to chromosomes 5 and 19p13.3, respectively (2,3). The genes encoding HCN3 and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively (4,5). |
| Gene ID | 610 |
|---|---|
| Other Names | BCNG-2; BCNG2; EIG17; FEB2; GEFSP11; HAC-1; HAC1; trls; HCN2_HUMAN; HCN2; Brain cyclic nucleotide-gated channel 2 (BCNG-2); HCN2_MOUSE; Hyperpolarization-activated cation channel 1 (HAC-1); HCN2_RAT; hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; hyperpolarization activated cyclic nucleotide gated potassium channel 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:50-200,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HCN2 (HGNC:4846) |
|---|---|
| Synonyms | BCNG2 |
| Function | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed throughout the brain. Detected at low levels in heart. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99833
