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C5a anaphylatoxin Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P01031 |
| Other Accession | P01031 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 188305 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C5a anaphylatoxin |
| Epitope Specificity | 701-751/1676 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 anaphylatoxin-like domain. Contains 1 NTR domain. |
| SUBUNIT | C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Interacts with tick complement inhibitor. |
| DISEASE | Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Activation of the complement system plays a key role in normal inflammatory response to injury but may cause substantial injury when activated inappropriately. The complement system is activated either through the classical (antibody induced) or the alternative (microbial surface, polysacharride induced) pathway, both leading to the formation of the C5b9 complex. Fluid phase binding of the multifunctional glycoprotein S protein (vitronectin) to C5b9 leads to the formation of a cytolytically inactive complex, SC5b9, which is unable to attach to cells. |
| Gene ID | 727 |
|---|---|
| Other Names | C5D; C5a; C5b; CPAMD4; ECLZB; ARMD15; C9D; CO5_HUMAN; C5; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; CO9_HUMAN; C9; CO8A_HUMAN; C8A; Complement component 8 subunit alpha; CO7_HUMAN; C7; CO6_HUMAN; C6; complement C5; complement component 5; prepro-C5; C5a anaphylatoxin |
| Dilution | IF=1:100-500,Flow-Cyt=2ug/Test,IHC-P=1:100-500,IHC-F=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | C5 {ECO:0000303|PubMed:1984448, ECO:0000312|HGNC:HGNC:1331} |
|---|---|
| Function | Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:6554279). Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279). |
| Cellular Location | Secreted. [C5a anaphylatoxin]: Secreted |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99909
