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KLF10 Rabbit pAb
- 产品详情
- 实验流程
| Primary Accession | Q13118 |
|---|---|
| Other Accession | Q13118 |
| Reactivity | Human |
| Predicted | Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52555 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TIEG1 |
| Epitope Specificity | 401-480/480 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. |
| Post-translational modifications | Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KLF10 is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5'-GGTGTG-3'. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer. |
| Gene ID | 7071 |
|---|---|
| Other Names | EGR-alpha; EGRA; TIEG; TIEG1; EGR[a]; Egral; Gdnfif; TIEG-1; mGIF; KLF10_HUMAN; KLF10; Transforming growth factor-beta-inducible early growth response protein 1 (TGFB-inducible early growth response protein 1 | TIEG-1); KLF10_MOUSE; GDNF-inducible factor; Transcription factor GIF (mGIF); KLF10_RAT; Zinc finger transcription factor homolog CPG20; Cpg20; KLF transcription factor 10; TGFB inducible early growth response; Kruppel like factor 10; early growth response alpha |
| Dilution | ICC/IF=1:50-200 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KLF10 |
|---|---|
| Synonyms | TIEG, TIEG1 |
| Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:O89091}. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP99914
