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SMYD2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9NRG4 |
| Other Accession | Q9NRG4 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49688 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SMYD2 |
| Epitope Specificity | 245-340/433 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 MYND-type zinc finger. Contains 1 SET domain. |
| SUBUNIT | Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 (By similarity). Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008] |
| Gene ID | 56950 |
|---|---|
| Other Names | HSKM-B; KMT3C; ZMYND14; 1110020E07Rik; 4930402C15; SMYD2_BOVIN; SMYD2; Histone methyltransferase SMYD2; SET and MYND domain-containing protein 2; 2.1.1.-; SMYD2_HUMAN; Lysine N-methyltransferase 3C; SMYD2_MOUSE; SMYD2_PIG; SMYD2_RAT; SET and MYND domain containing 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SMYD2 |
|---|---|
| Synonyms | KMT3C |
| Function | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99915
