癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRSS1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P07477 |
| Other Accession | P07477 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 26558 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PRSS1 |
| Epitope Specificity | 51-150/247 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. |
| Post-translational modifications | Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122. |
| DISEASE | Defects in PRSS1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008] |
| Gene ID | 5644 |
|---|---|
| Other Names | TRP1; TRY1; TRY4; TRYP1; Try-1; Trygn16; PTRYI; RATPTRYI; TRY1_BOVIN; PRSS1; Anionic trypsin I; Anionic trypsin-I; Beta-trypsin; Cationic trypsin; Pretrypsinogen I; Trypsin I; Trypsin-I; 3.4.21.4; TRY1_HUMAN; Cationic trypsinogen; Trypsin-1; TRY1_RAT; Anionic trypsin-1; serine protease 1; trypsin 1; protease, serine 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PRSS1 (HGNC:9475) |
|---|---|
| Function | Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates. |
| Cellular Location | Secreted, extracellular space. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP99934
