癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MOV10L1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9BXT6 |
| Other Accession | Q9BXT6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 135293 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MOV10L1 |
| Epitope Specificity | 431-530/1211 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] |
| Gene ID | 54456 |
|---|---|
| Other Names | CHAMP; DJ402G11.8; SPGF73; Csm; M10L1_HUMAN; MOV10L1; Moloney leukemia virus 10-like protein 1 (MOV10-like protein 1); 3.6.4.13; M10L1_MOUSE; Cardiac helicase activated by MEF2 protein; Cardiac-specific RNA helicase; Moloney leukemia virus 10-like protein 1 homolog (MOV10-like protein 1 homolog); Mov10 like RNA helicase 1; Mov10 (mouse)-like 1; Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse); Mov10 RISC complex RNA helicase like 1; Mov10 like RISC complex RNA helicase 1; cardiac helicase activated by MEF2C protein |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MOV10L1 (HGNC:7201) |
|---|---|
| Function | ATP-dependent 5'-3' RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q99MV5}. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV5} |
| Tissue Location | [Isoform 1]: Specifically expressed in testis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99941
