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MRP4/ABCC4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O15439 |
| Other Accession | O15439 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 149527 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MRP4 |
| Epitope Specificity | 751-880/1325 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. |
| SUBUNIT | Membrane; Multi-pass membrane protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008]. |
| Gene ID | 10257 |
|---|---|
| Other Names | MOAT-B; MOATB; MRP4; ABCC4-N1; D630049P08Rik; MRP4_HUMAN; ABCC4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B (MOAT-B); Multidrug resistance-associated protein 4; 7.6.2.-; 7.6.2.2; 7.6.2.3; ATP binding cassette subfamily C member 4 (PEL blood group); ATP-binding cassette, sub-family C (CFTR/MRP), member 4; ATP binding cassette subfamily C member 4; canalicular multispecific organic anion transporter (ABC superfamily); bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); multispecific organic anion transporter B |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ABCC4 |
|---|---|
| Synonyms | MOATB, MRP4 {ECO:0000303|PubMed:29175180 |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (PubMed:11856762, PubMed:12523936, PubMed:15364914, PubMed:38886124, PubMed:40138312). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430, PubMed:38886124, PubMed:40138312). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). May contribute to hepatic, intestinal and renal excretion of steroid conjugates. Selectively transports steroid glucuronates and sulfates. Mediates the efflux of estrogens glucuronated at C-16 and C-17 positions, but has no transporter activity toward estrogens glucuronated at C-3. Has high affinity for dehydroepiandrosterone-3-sulfate and can also transport testosterone-17-sulfate, but has no transporter activity toward androsterone and etiocholanolone sulfate conjugates. Does not transport estrone 3-sulfate (PubMed:29175180, PubMed:39993711). Displays low affinity and high transport velocity for folates (PubMed:12036927). Transports a wide range of drugs and their metabolites. including anticancer, antiviral and antibiotic molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). May confer resistance to anticancer agents. Can mediate the efflux of methotrexate but is inactive toward polyglutaminated methotrexate, which is the predominant intracellular form (PubMed:11106685, PubMed:12036927). |
| Cellular Location | Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Its localization to the basolateral or apical membranes is tissue-dependent. |
| Tissue Location | Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP99960
