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EPHX2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P34913 |
| Other Accession | P34913 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 62616 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human EPHX2 |
| Epitope Specificity | 351-450/555 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. |
| SUBUNIT | Homodimer. |
| Post-translational modifications | The N-terminus is blocked.The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (Probable). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | EPHX2 belongs to the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
| Gene ID | 2053 |
|---|---|
| Other Names | ABHD20; CEH; SEH; Eph2; sEP; HYES_HUMAN; EPHX2; HYES_MOUSE; HYES_RAT; epoxide hydrolase 2; epoxide hydrolase 2, cytoplasmic; soluble epoxide hydrolase; bifunctional epoxide hydrolase |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | EPHX2 (HGNC:3402) |
|---|---|
| Function | Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12574510, PubMed:12869654, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators (PubMed:12574510, PubMed:12869654, PubMed:21217101, PubMed:22798687). |
| Cellular Location | Cytoplasm. Peroxisome. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99964
