癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FSH
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
Application 
| IHC |
|---|---|
| Primary Accession | P23945 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 78238 Da |
| Gene ID | 2492 |
|---|---|
| Other Names | Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor, FSHR, LGR1 |
| Dilution | IHC~~1:100~500 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FSH is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FSHR |
|---|---|
| Synonyms | LGR1 |
| Function | G protein-coupled receptor for follitropin, the follicle- stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Mediates FSH signaling through cAMP/protein kinase A (PKA) and phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathways to regulate ovarian follicular development and steroidogenesis (PubMed:24058690). Has diverse extragonadal functions: signals via a GNAI2-coupled FSHR on osteoclasts and their precursors, resulting in activation of MEK/ERK, NF-kappa-B, and AKT pathways and thus increases osteoclastogenesis and bone resorption (By similarity). Regulates glucose-stimulated insulin secretion in pancreatic beta-cells in a bell curve manner, with moderate FSH levels promoting insulin secretion via Galphas/cAMP/PKA pathways while high FSH levels inhibit this effect through Galphai coupling (By similarity). In adipose tissue, inhibits thermogenesis by suppressing UCP1 expression and promotes lipogenesis via CREB/PPARgamma pathways (By similarity). Also affects hepatic cholesterol metabolism by increasing serum total and low-density- lipoprotein cholesterol (LDL-C) by inhibiting the expression of LDL receptor (LDLR) (PubMed:26583582). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Sertoli cells and ovarian granulosa cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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