CA 19-9

Mouse Monoclonal Antibody (Mab)

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC
Primary Accession	Q969X2
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Calculated MW	38068 Da

Additional Information
Gene ID	30815
Other Names	Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 6, 2.4.99.-, GalNAc alpha-2, 6-sialyltransferase VI, ST6GalNAc VI, ST6GalNAcVI, hST6GalNAc VI, Sialyltransferase 7F, SIAT7-F, ST6GALNAC6, SIAT7F
Dilution	IHC~~1:100~500
Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	CA 19-9 is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	ST6GALNAC6
Synonyms	SIAT7F
Function	Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3- linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity).
Cellular Location	Golgi apparatus membrane; Single- pass type II membrane protein
Tissue Location	Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.