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Anti-ADAM9 Reference Antibody (Imgc936)

Recombinant Antibody

Anti-ADAM9 Reference Antibody (Imgc936) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
Human ADAM9 CHOS cells were stained with Anti-ADAM9 Reference Antibody (Imgc936) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.3912 nM.
The endocytosis ratio Imgc936 by Human ADAM9 HT29 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 50% at antibody concentration of 1 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q13443
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	90556 Da

Additional Information
Target/Specificity	ADAM9
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	ADAM9
Synonyms	KIAA0021, MCMP, MDC9, MLTNG
Function	Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell- matrix interactions and regulate the motility of cells via interactions with integrins.
Cellular Location	[Isoform 1]: Cell membrane; Single-pass type I membrane protein
Tissue Location	Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol