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Anti-IL-5Ra/ CD125 Reference Antibody (benralizumab)

Recombinant Antibody

Anti-IL-5Ra/ CD125 Reference Antibody (benralizumab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-IL-5Ra/ CD125 Reference Antibody (benralizumab) is 98.82%, determined by SEC-HPLC.
Immobilized human IL 5Rα His at 2 ug/mL can bind Anti-IL-5Ra/ CD125 Reference Antibody (benralizumab), EC50=0.001639 ug/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q01344
Reactivity	Rat, Human, Mouse
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	47685 Da

Additional Information
Target/Specificity	IL-5Ra/ CD125
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	IL5RA
Synonyms	IL5R
Function	Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5 (PubMed:1495999, PubMed:22528658). In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124).
Cellular Location	Membrane; Single-pass type I membrane protein.
Tissue Location	Expressed on eosinophils and basophils.