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Anti-Complement C2 Reference Antibody (ARGX-117)

Recombinant Antibody

Anti-Complement C2 Reference Antibody (ARGX-117) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-Complement C2 Reference Antibody (ARGX-117) is 100%, determined by SEC-HPLC.
Immobilized human Complement C2 Protein at 2 ug/mL can bind Anti-Complement C2 Reference Antibody (ARGX-117), EC50=0.004283 ug/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P06681
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	83268 Da

Additional Information
Target/Specificity	Complement C2
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	C2 {ECO:0000303\|PubMed:2949737, ECO:0000312\|HGNC:HGNC:1248}
Function	Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12878586, PubMed:17027507, PubMed:18204047, PubMed:39914456, PubMed:39814882). Component C2 is part of the classical, lectin and GZMK complement systems (PubMed:12878586, PubMed:17027507, PubMed:18204047, PubMed:22691502, PubMed:39914456).
Cellular Location	Secreted. Cell surface. Note=Recruited to the surface of pathogens by complement C3b and complement C4b opsonins