Anti-ENTPD1 / CD39 Reference Antibody (TTX-030)

Recombinant Antibody

Anti-ENTPD1 / CD39 Reference Antibody (TTX-030) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
The purity of Anti-ENTPD1 / CD39 Reference Antibody (TTX-030)is more than 99.83% ,determined by SEC-HPLC.
TTX-030 inhibited the tumor growth of MOLP-8 on NCG mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 99.3% at 20 mpk at D25.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, Kinetics, Animal Model
Primary Accession	P49961
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4
Calculated MW	57965 Da

Additional Information
Target/Specificity	ENTPD1 / CD39
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO Cell
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

Protein Information
Name	ENTPD1 (HGNC:3363)
Function	Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (PubMed:8955160, PubMed:8996251).
Cellular Location	Membrane; Multi-pass membrane protein. Membrane, caveola
Tissue Location	Expressed primarily on activated lymphoid cells (PubMed:7930580). Also expressed in endothelial tissues (PubMed:8955160). Highly expressed in placenta, lung, skeletal muscle, kidney (PubMed:8955160).