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Anti-MUC16 Reference Antibody (oregovomab)

Recombinant Antibody

Anti-MUC16 Reference Antibody (oregovomab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%.
The purity of Anti-MUC16 Reference Antibody (oregovomab) is more than 95%, determined by SEC-HPLC.
HELA Cell Line were stained with Anti-MUC16 Reference Antibody (oregovomab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.01 ug/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q8WXI7
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	1519175 Da

Additional Information
Target/Specificity	MUC16
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	MUC16 (HGNC:15582)
Function	Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Cellular Location	Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain
Tissue Location	Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol