Anti-PVR / CD155 Reference Antibody (Ntx1088)

Recombinant Antibody

Anti-PVR / CD155 Reference Antibody (Ntx1088) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
The purity of Anti-PVR / CD155 Reference Antibody (Ntx1088)is more than 99.38% ,determined by SEC-HPLC.
Human CD155 CHOK cells were stained with Anti-PVR / CD155 Reference Antibody (Ntx1088) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC479=0.08349 µg/mL

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, Kinetics, Animal Model
Primary Accession	P15151
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	45303 Da

Additional Information
Target/Specificity	PVR / CD155
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO Cell
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

Protein Information
Name	PVR
Synonyms	PVS
Function	Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
Cellular Location	[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein [Isoform Beta]: Secreted.

Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

Application Protocols

Provided below are standard protocols that you may find useful for product applications.