> 首页 > 产品 > 一抗 > 基因重组 > Anti-ICAM1 / CD54 Reference Anticody (Enlimomab)

Anti-ICAM1 / CD54 Reference Anticody (Enlimomab)

Recombinant Antibody

Anti-ICAM1 / CD54 Reference Antibody (Enlimomab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-ICAM1 / CD54 Reference Anticody (Enlimomab) is 97.77%, determined by SEC-HPLC.
Immobilized Human ICAM1 / CD54, His tag at 2 µg/mL can bind Enlimomab, EC50= 0.01487 µg/mL.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P05362
Reactivity	Human
Clonality	Monoclonal
Isotype	mIgG2a
Calculated MW	57825 Da

Additional Information
Target/Specificity	ICAM1 / CD54
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	ICAM1 (HGNC:5344)
Function	Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength (PubMed:3086451, PubMed:3340213, PubMed:38195629). Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (PubMed:17875742). Promotes cell aggregation in epithelial cells through interaction with MUC1 (PubMed:11173916).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Expressed on non-hematopoietic cells such as vascular endothelial cells, thymic epithelial cells, certain other epithelial cells, and fibroblasts, and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T lymphocyte blasts, and germinal center dendritic cells in tonsils, lymph nodes, and Peyer's patches (PubMed:3086451). Expressed in low amounts on peripheral blood leukocytes (PubMed:3086451).