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Anti-RGMC / HFE2 Reference Antibody (DISC-0974)

Recombinant Antibody

Anti-RGMC / HFE2 Reference Antibody (DISC-0974) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-RGMC / HFE2 Reference Antibody (DISC-0974) is 98.22 %, determined by SEC-HPLC.
cells were stained with Anti-RGMC / HFE2 Reference Antibody (DISC-0974) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.031 ug/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q6ZVN8
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	45080 Da

Additional Information
Target/Specificity	RGMC / HFE2
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	HJV (HGNC:4887)
Synonyms	HFE2, RGMC
Function	Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966).
Cellular Location	Cell membrane; Lipid-anchor, GPI- anchor. Note=Also released in the extracellular space
Tissue Location	Adult and fetal liver, heart, and skeletal muscle.