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Anti-ROR2 Reference Antibody (ozuriftamab vedotin)

Recombinant Antibody

Anti-ROR2 Reference Antibody (ozuriftamab vedotin) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-ROR2 Reference Antibody (ozuriftamab vedotin) is 99.74%, determined by SEC-HPLC.
The drug-to-antibody ratio (DAR) of the Anti-ROR2 Reference Antibody (ozuriftamab vedotin) is 3.9.
Immobilized ROR2 at 2 µg/mL (30 uL/well) can bind Anti-ROR2 Reference Antibody (ozuriftamab vedotin)，EC50 is 0.160 ug/mL.
Human ROR2 CHO-S Cell Line were stained with Anti-ROR2 Reference Antibody (ozuriftamab vedotin) and negative control protein respectively, washed and then followed by PE and analyzed with FACS,The EC50 is 0.2650 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q01974
Reactivity	Human
Clonality	ADC
Isotype	IgG1
Calculated MW	104757 Da

Additional Information
Target/Specificity	ROR2
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	MMAE
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	ROR2
Synonyms	NTRKR2
Function	Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).
Cellular Location	Cell membrane; Single-pass type I membrane protein

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol